Affiliation:
1. Service d'Anatomie pathologique, APHP GHU Avicenne, UFR Médecine, Université Paris Nord Sorbonne Cité, Bobigny, France
Abstract
Squamous metaplasia of the appendix serosa is rare. We aimed to report the clinical and morphological features of 3 such cases. The patients presented with abdominal pain (n = 1 man, 2 women; age range, 29–35 years). The clinical diagnosis was appendicitis/periappendicitis (in the context of hydro/pyosalpinx). The surgical resected appendix showed several cystic and solid epithelial nests (1 mm and less) in the serosa/subserosa. Epithelial cells expressed p63, cytokeratin 5/6, as well as cytokeratins 7, 20, and CD10. Cystic and solid squamous and transitional epithelial nests of the appendix subserosa/serosa in adult patients may be revealed by acute appendicitis/ periappendicitis. The presence of such lesions, metaplastic or vestigial in nature, should be acknowledged since they can be misdiagnosed with metastatic epithelial tumor nests or they may undergo malignant change.
Publisher
International College of Surgeons
Cited by
2 articles.
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1. Non-neoplastic Lesions of the Appendix;Surgical Pathology of the Gastrointestinal System;2022
2. Appendix Cyst;International Journal of Surgical Pathology;2019-06-24