Survival Determinants after Pancreatectomy With Vascular Resection for Pancreatic Cancer

Abstract

To investigate the morbidity, mortality, and survival of patients with pancreatic cancer after pancreatectomy with vascular resection and to clarify the favorable prognostic survival factors. Pancreatic cancer is a malignant tumor. Many revisions have been made to surgical procedures to improve the prognosis of resectable pancreatic cancer. Several studies have compared no-vein and vein resection with pancreaticoduodenectomy, recording their feasibility and equal rates of operative mortality, incidence, and survival. Factors identified as potentially relevant to survival outcomes include population, perioperative treatment, and clinical pathologic factors, but these are still controversial. From January 1, 2003, to December 31, 2010, 63 patients with advanced pancreatic cancer underwent pancreatectomy with vascular resection. They were divided into 2 groups: one group had a survival time of <2 years (group 1) and the other a survival time of >2 years (group 2). Their clinical data, surgical techniques, perioperative parameters, and histopathologic data from a prospective database were analyzed. Major venous resection with reconstruction was performed in 61 patients (96.83%); major venous and artery resection with reconstruction in 1 patient (1.58%); and arterial resection with reconstruction in another patient (1.58%). The median survival time and the actuarial 1-, 2-, and 3-year survival rates for all patients are 19.94 months and 45.0%, 27.4%, and 17.6%, respectively. Group 1 contained 42 patients and group 2 contained 21 patients. A multivariate analysis identified tumor size, tumor differentiation, lymph-node status, nerve invasion, and metastasis (TNM) staging of the pancreatic cancer, tumor grade, operating time, and chemotherapy after surgery as independent predictors of long-term survival. TNM staging, tumor grade, operating time, and chemotherapy are independent predictors of survival after pancreatectomy.