Factors Affecting Blood Flow at the Tip of the Reconstructed Gastric Tube During Esophagectomy: A Study Using Indocyanine Green Fluorescence Angiography

Abstract

The objective of this study was to clarify the factors affecting blood flow at the tip of the gastric tube during esophagectomy using indocyanine green (ICG) fluorescence angiography. The time until enhancement of the gastric tube tip determined using ICG fluorescence imaging is a useful indicator of blood flow, and has been shown not to differ significantly according to the connection status of the right or left gastroepiploic artery. Using ICG fluorescence imaging, the time until enhancement of the gastric tube tip was measured in 50 patients undergoing esophagectomy. Blood flow at the gastric tube tip was compared between 2 groups of patients: those in whom a connecting vessel from the left gastro-epiploic artery to the short gastric artery (l-s GA) was present and those in whom it was absent. The factors affecting blood flow to the gastric tube tip were also investigated using univariate and multivariate logistic regression analysis. The median time taken for the gastric tube tip to show enhancement with ICG was significantly shorter in the group with an l-s GA connection (P = 0.02). Multivariate analysis showed that the absence of an l-s GA connection (P = 0.04) and presence of arteriosclerosis-related disease (P = 0.02) were significant independent factors that delayed blood flow to the gastric tube. It is essential to preserve the whole vessel arcade of the greater curvature to achieve good perfusion of the gastric tube with blood. The presence of arteriosclerosis-related disease is a major factor affecting the safety of anastomosis during gastric tube reconstruction.