NCCN Guidelines® Insights: Merkel Cell Carcinoma, Version 1.2024

Author:

Schmults Chrysalyne D.1,Blitzblau Rachel2,Aasi Sumaira Z.3,Alam Murad4,Amini Arya5,Bibee Kristin6,Bolotin Diana7,Bordeaux Jeremy8,Chen Pei-Ling9,Contreras Carlo M.10,DiMaio Dominick11,Donigan Jessica M.12,Farma Jeffrey M.13,Ghosh Karthik14,Harms Kelly15,Ho Alan L.16,Lukens John Nicholas17,Manber Susan18,Mark Lawrence19,Medina Theresa20,Nehal Kishwer S.16,Nghiem Paul21,Olino Kelly22,Park Soo23,Patel Tejesh24,Puzanov Igor25,Rich Jason26,Sekulic Aleksandar14,Shaha Ashok R.16,Srivastava Divya27,Thomas Valencia28,Tomblinson Courtney29,Venkat Puja30,Xu Yaohui Gloria31,Yu Siegrid32,Yusuf Mehran33,McCullough Beth34,Espinosa Sara34

Affiliation:

1. Dana-Farber/Brigham and Women’s Cancer Center

2. Duke Cancer Institute

3. Stanford Cancer Institute

4. Robert H. Lurie Comprehensive Cancer Center of Northwestern University

5. City of Hope National Medical Center

6. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

7. The UChicago Medicine Comprehensive Cancer Center

8. Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

9. Moffitt Cancer Center

10. The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

11. Fred & Pamela Buffett Cancer Center

12. Huntsman Cancer Institute at the University of Utah

13. Fox Chase Cancer Center

14. Mayo Clinic Comprehensive Cancer Center

15. University of Michigan Rogel Cancer Center

16. Memorial Sloan Kettering Cancer Center

17. Abramson Cancer Center at the University of Pennsylvania

18. Publicis Health

19. Indiana University Melvin and Bren Simon Comprehensive Cancer Center

20. University of Colorado Cancer Center

21. Fred Hutchinson Cancer Center

22. Yale Cancer Center/Smilow Cancer Hospital

23. UC San Diego Moores Cancer Center

24. The University of Tennessee Health Science Center

25. Roswell Park Comprehensive Cancer Center

26. Siteman Cancer Center at Barnes-Jewish Hospital and Washington UniversitySchool of Medicine

27. UT Southwestern Simmons Comprehensive Cancer Center

28. The University of Texas MD Anderson Cancer Center

29. Vanderbilt-Ingram Cancer Center

30. UCLA Jonsson Comprehensive Cancer Center

31. University of Wisconsin Carbone Cancer Center

32. UCSF Helen Diller Family Comprehensive Cancer Center

33. O’Neal Comprehensive Cancer Center at UAB

34. National Comprehensive Cancer Network

Abstract

The NCCN Guidelines for Merkel Cell Carcinoma (MCC) provide recommendations for diagnostic workup, clinical stage, and treatment options for patients. The panel meets annually to discuss updates to the guidelines based on comments from expert review from panel members, institutional review, as well as submissions from within NCCN and external organizations. These NCCN Guidelines Insights focus on the introduction of a new page for locally advanced disease in the setting of clinical node negative status, entitled “Clinical N0 Disease, Locally Advanced MCC.” This new algorithm page addresses locally advanced disease, and the panel clarifies the meaning behind the term “nonsurgical” by further defining locally advanced disease. In addition, the guideline includes the management of in-transit disease and updates to the systemic therapy options.

Publisher

Harborside Press, LLC

Reference54 articles.

1. Merkel cell carcinoma: current US incidence and projected increases based on changing demographics;Paulson KG,2018

2. Assessment of age, period, and birth cohort effects and trends in Merkel cell carcinoma incidence in the United States;Jacobs D,2021

3. Dramatic increase in the incidence and mortality from Merkel cell carcinoma in the United States;Fitzgerald TL,2015

4. International increases in Merkel cell carcinoma incidence rates between 1997 and 2016;Olsen CM,2021

5. Skin cancers associated with HIV infection and solid-organ transplantation among elderly adults;Lanoy E,2010

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