Stabilization of Metastatic Uterine Leiomyosarcoma Using Pembrolizumab

Author:

Cotangco Katherine1,Meram Mary2,Lowe M. Patrick3

Affiliation:

1. 1Department of Obstetrics and Gynecology, University of Illinois;

2. 2Department of Obstetrics and Gynecology, Amita Health Hospital; and

3. 3Gynecologic Cancer Institute, Chicago, Illinois.

Abstract

The estimated 5-year survival rate for patients with stage IV uterine leiomyosarcoma is 29%, with a median survival of <1 year. This report describes a patient with stage IVB leiomyosarcoma who experienced stable disease for 15 months on pembrolizumab. A woman aged 62 years, gravida 2 para 2, with postmenopausal bleeding and a necrotic uterine fibroid underwent a dilation and curettage and was diagnosed with uterine leiomyosarcoma. CT imaging showed pulmonary and bony metastasis. She underwent surgical staging with biopsy-proved stage IVB disease. A mixed partial response was noted using first- and second-line chemotherapy. Molecular tumor profiling confirmed PD-L1 expression. The patient was started on pembrolizumab, and at the time of writing she is status post 23 cycles with stable disease. Pembrolizumab was well tolerated and aided prolonged disease stabilization.

Publisher

Harborside Press, LLC

Subject

Oncology

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