NCCN Guidelines® Insights: B-Cell Lymphomas, Version 5.2021

Author:

Zelenetz Andrew D.1,Gordon Leo I.2,Chang Julie E.3,Christian Beth4,Abramson Jeremy S.5,Advani Ranjana H.6,Bartlett Nancy L.7,Budde L. Elizabeth8,Caimi Paolo F.9,De Vos Sven10,Dholaria Bhagirathbhai11,Fakhri Bita12,Fayad Luis E.13,Glenn Martha J.14,Habermann Thomas M.15,Hernandez-Ilizaliturri Francisco16,Hsi Eric9,Hu Boyu14,Kaminski Mark S.17,Kelsey Christopher R.18,Khan Nadia19,Krivacic Susan20,LaCasce Ann S.21,Lim Megan22,Narkhede Mayur23,Rabinovitch Rachel24,Ramakrishnan Praveen25,Reid Erin26,Roberts Kenneth B.27,Saeed Hayder28,Smith Stephen D.29,Svoboda Jakub22,Swinnen Lode J.30,Tuscano Joseph31,Vose Julie M.32,Dwyer Mary A.33,Sundar Hema33

Affiliation:

1. 1Memorial Sloan Kettering Cancer Center;

2. 2Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

3. 3University of Wisconsin Carbone Cancer Center;

4. 4The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

5. 5Massachusetts General Hospital Cancer Center;

6. 6Stanford Cancer Institute;

7. 7Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

8. 8City of Hope National Medical Center;

9. 9Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

10. 10UCLA Jonsson Comprehensive Cancer Center;

11. 11Vanderbilt-Ingram Cancer Center;

12. 12UCSF Helen Diller Family Comprehensive Cancer Center;

13. 13The University of Texas MD Anderson Cancer Center;

14. 14Huntsman Cancer Institute at the University of Utah;

15. 15Mayo Clinic Cancer Center;

16. 16Roswell Park Comprehensive Cancer Center;

17. 17University of Michigan Rogel Cancer Center;

18. 18Duke Cancer Institute;

19. 19Fox Chase Cancer Center;

20. 20Consultant;

21. 21Dana-Farber/Brigham and Women’s Cancer Center;

22. 22Abramson Cancer Center at the University of Pennsylvania;

23. 23O'Neal Comprehensive Cancer Center at UAB;

24. 24University of Colorado Cancer Center;

25. 25UT Southwestern Simmons Comprehensive Cancer Center;

26. 26UC San Diego Moores Cancer Center;

27. 27Yale Cancer Center/Smilow Cancer Hospital;

28. 28Moffitt Cancer Center;

29. 29Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

30. 30The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

31. 31UC Davis Comprehensive Cancer Center;

32. 32Fred & Pamela Buffett Cancer Center; and

33. 33National Comprehensive Cancer Network.

Abstract

In the last decade, a better understanding of the molecular pathogenesis of B-cell non-Hodgkin lymphomas has resulted in the development of novel targeted therapies, such as small molecule inhibitors of select kinases in the B-cell receptor pathway, antibody–drug conjugates, and small molecules that target a variety of proteins (eg, CD-19, EZH2, and XPO-1–mediated nuclear export). Anti-CD19 CAR T-cell therapy, first approved for relapsed/refractory (R/R) diffuse large B-cell lymphoma, has also emerged as a novel treatment option for R/R follicular lymphoma and mantle cell lymphoma. These NCCN Guideline Insights highlight the new targeted therapy options included in the NCCN Guidelines for B-Cell Lymphomas for the treatment of R/R disease.

Publisher

Harborside Press, LLC

Subject

Oncology

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