Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology

Author:

Ajani Jaffer A.1,D’Amico Thomas A.2,Bentrem David J.3,Cooke David4,Corvera Carlos5,Das Prajnan1,Enzinger Peter C.6,Enzler Thomas7,Farjah Farhood8,Gerdes Hans9,Gibson Michael10,Grierson Patrick11,Hofstetter Wayne L.1,Ilson David H.10,Jalal Shadia12,Keswani Rajesh N.3,Kim Sunnie13,Kleinberg Lawrence R.14,Klempner Samuel15,Lacy Jill16,Licciardi Frank17,Ly Quan P.18,Matkowskyj Kristina A.19,McNamara Michael20,Miller Aaron21,Mukherjee Sarbajit22,Mulcahy Mary F.3,Outlaw Darryl23,Perry Kyle A.24,Pimiento Jose25,Poultsides George A.26,Reznik Scott27,Roses Robert E.28,Strong Vivian E.10,Su Stacey29,Wang Hanlin L.30,Wiesner Georgia11,Willett Christopher G.2,Yakoub Danny31,Yoon Harry32,McMillian Nicole R.33,Pluchino Lenora A.33

Affiliation:

1. The University of Texas MD Anderson Cancer Center

2. Duke Cancer Institute

3. Robert H. Lurie Comprehensive Cancer Center of Northwestern University

4. UC Davis Comprehensive Cancer Center

5. UCSF Helen Diller Family Comprehensive Cancer Center

6. Dana-Farber/Brigham and Women’s Cancer Center

7. University of Michigan Rogel Cancer Center

8. Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance

9. Memorial Sloan Kettering Cancer Center

10. Vanderbilt-Ingram Cancer Center

11. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine

12. Indiana University Melvin and Bren Simon Comprehensive Cancer Center

13. University of Colorado Cancer Center

14. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

15. Massachusetts General Hospital Cancer Center

16. Yale Cancer Center/Smilow Cancer Hospital

17. Patient advocate

18. Fred & Pamela Buffett Cancer Center

19. University of Wisconsin Carbone Cancer Center

20. Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

21. UC San Diego Moores Cancer Center

22. Roswell Park Comprehensive Cancer Center

23. O’Neal Comprehensive Cancer Center at UAB

24. The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

25. Moffitt Cancer Center

26. Stanford Cancer Institute

27. UT Southwestern Simmons Comprehensive Cancer Center

28. Abramson Cancer Center at the University of Pennsylvania

29. Fox Chase Cancer Center

30. UCLA Jonsson Comprehensive Cancer Center

31. St. Jude Children's Research Hospital/The University of Tennessee Health Science Center

32. Mayo Clinic Cancer Center

33. National Comprehensive Cancer Network

Abstract

Cancers originating in the esophagus or esophagogastric junction constitute a major global health problem. Esophageal cancers are histologically classified as squamous cell carcinoma (SCC) or adenocarcinoma, which differ in their etiology, pathology, tumor location, therapeutics, and prognosis. In contrast to esophageal adenocarcinoma, which usually affects the lower esophagus, esophageal SCC is more likely to localize at or higher than the tracheal bifurcation. Systemic therapy can provide palliation, improved survival, and enhanced quality of life in patients with locally advanced or metastatic disease. The implementation of biomarker testing, especially analysis of HER2 status, microsatellite instability status, and the expression of programmed death-ligand 1, has had a significant impact on clinical practice and patient care. Targeted therapies including trastuzumab, nivolumab, ipilimumab, and pembrolizumab have produced encouraging results in clinical trials for the treatment of patients with locally advanced or metastatic disease. Palliative management, which may include systemic therapy, chemoradiation, and/or best supportive care, is recommended for all patients with unresectable or metastatic cancer. Multidisciplinary team management is essential for all patients with locally advanced esophageal or esophagogastric junction cancers. This selection from the NCCN Guidelines for Esophageal and Esophagogastric Junction Cancers focuses on the management of recurrent or metastatic disease.

Publisher

Harborside Press, LLC

Subject

Oncology

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