Concomitant Venetoclax and Imatinib for Comanaging Chronic Lymphocytic Leukemia and Chronic Myeloid Leukemia: A Case Report

Author:

Przespolewski Eugene R.1,Baron Jeffrey1,Kashef Farshid12,Fu Kai1,Jani Sait Sheila N.1,Hernandez-Ilizaliturri Francisco1,Thompson James1

Affiliation:

1. Roswell Park Comprehensive Cancer Center, Buffalo, New York

2. Kaleida Health, Buffalo, New York

Abstract

Patients with synchronous malignancies can be problematic to diagnose and manage because workup and therapeutic targeting for each individual malignancy must be coordinated carefully. This report presents a patient with concurrent chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL) managed with concomitant venetoclax and imatinib. Because imatinib is a moderate cytochrome P450 3A4 inhibitor, close monitoring is required when using with a substrate of 3A4 such as venetoclax. Although the target dose of venetoclax is 400 mg, it was capped at 100 mg due to the interaction. Despite the interaction and possible enhancement of toxicities, the patient has tolerated therapy well, and both diseases have responded to this novel approach. In addition, because aberrant BCL-2 activity has been implicated in CML, the use of venetoclax may contribute to success in the management of this patient’s CML. This case report represents the safe concomitant use of venetoclax and imatinib in a patient with synchronous CML and CLL.

Publisher

Harborside Press, LLC

Subject

Oncology

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1. Multiple drugs;Reactions Weekly;2023-09-02

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