Histiocytic Neoplasms, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

Author:

Go Ronald S.1,Jacobsen Eric2,Baiocchi Robert3,Buhtoiarov Ilia4,Butler Erin B.5,Campbell Patrick K.6,Coulter Don W.7,Diamond Eli8,Flagg Aron9,Goodman Aaron M.10,Goyal Gaurav11,Gratzinger Dita12,Hendrie Paul C.13,Higman Meghan14,Hogarty Michael D.15,Janku Filip16,Karmali Reem17,Morgan David18,Raldow Anne C.19,Stefanovic Alexandra20,Tantravahi Srinivas K.21,Walkovich Kelly22,Zhang Ling23,Bergman Mary Anne24,Darlow Susan D.24

Affiliation:

1. 1Mayo Clinic Cancer Center;

2. 2Dana-Farber/Brigham and Women's Cancer Center | Massachusetts General Hospital Cancer Center;

3. 3The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

4. 4Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute Cleveland Clinic Children's Hospital;

5. 5UT Southwestern Simmons Comprehensive Cancer Center;

6. 6St. Jude Children's Research Hospital/The University of Tennessee Health Science Center;

7. 7Fred & Pamela Buffett Cancer Center;

8. 8Memorial Sloan Kettering Cancer Center;

9. 9Yale Cancer Center/Smilow Cancer Hospital;

10. 10UC San Diego Moores Cancer Center;

11. 11O'Neal Comprehensive Cancer Center at UAB;

12. 12Stanford Cancer Institute;

13. 13Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

14. 14Roswell Park Comprehensive Cancer Center;

15. 15Abramson Cancer Center at the University of Pennsylvania;

16. 16The University of Texas MD Anderson Cancer Center;

17. 17Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

18. 18Vanderbilt-Ingram Cancer Center;

19. 19UCLA Jonsson Comprehensive Cancer Center;

20. 20Duke Cancer Institute;

21. 21Huntsman Cancer Institute at the University of Utah;

22. 22University of Michigan Rogel Cancer Center;

23. 23Moffitt Cancer Center; and

24. 24National Comprehensive Cancer Network

Abstract

Histiocytic neoplasms are rare hematologic disorders accounting for less than 1% of cancers of the soft tissue and lymph nodes. Clinical presentation and prognosis of these disorders can be highly variable, leading to challenges for diagnosis and optimal management of these patients. Treatment often consists of systemic therapy, and recent studies support use of targeted therapies for patients with these disorders. Observation (“watch and wait”) may be sufficient for select patients with mild disease. These NCCN Guidelines for Histiocytic Neoplasms include recommendations for diagnosis and treatment of adults with the most common histiocytic disorders: Langerhans cell histiocytosis, Erdheim-Chester disease, and Rosai-Dorfman disease.

Publisher

Harborside Press, LLC

Subject

Oncology

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