NCCN Guidelines Insights: Rectal Cancer, Version 6.2020

Author:

Benson Al B.1,Venook Alan P.2,Al-Hawary Mahmoud M.3,Arain Mustafa A.2,Chen Yi-Jen4,Ciombor Kristen K.5,Cohen Stacey6,Cooper Harry S.7,Deming Dustin8,Garrido-Laguna Ignacio9,Grem Jean L.10,Gunn Andrew11,Hoffe Sarah12,Hubbard Joleen13,Hunt Steven14,Kirilcuk Natalie15,Krishnamurthi Smitha16,Messersmith Wells A.17,Meyerhardt Jeffrey18,Miller Eric D.19,Mulcahy Mary F.1,Nurkin Steven20,Overman Michael J.21,Parikh Aparna22,Patel Hitendra23,Pedersen Katrina14,Saltz Leonard24,Schneider Charles25,Shibata David26,Skibber John M.21,Sofocleous Constantinos T.24,Stoffel Elena M.3,Stotsky-Himelfarb Eden27,Willett Christopher G.28,Johnson-Chilla Alyse29,Gurski Lisa A.29

Affiliation:

1. 1Robert H. Lurie Comprehensive Cancer Center of Northwestern University;

2. 2UCSF Helen Diller Family Comprehensive Cancer Center;

3. 3University of Michigan Rogel Cancer Center;

4. 4City of Hope National Medical Center;

5. 5Vanderbilt-Ingram Cancer Center;

6. 6Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance;

7. 7Fox Chase Cancer Center;

8. 8University of Wisconsin Carbone Cancer Center;

9. 9Huntsman Cancer Institute at the University of Utah;

10. 10Fred & Pamela Buffett Cancer Center;

11. 11O’Neal Comprehensive Cancer Center at UAB;

12. 12Moffitt Cancer Center;

13. 13Mayo Clinic Cancer Center;

14. 14Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine;

15. 15Stanford Cancer Institute;

16. 16Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute;

17. 17University of Colorado Cancer Center;

18. 18Dana-Farber/Brigham and Women’s Cancer Center;

19. 19The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute;

20. 20Roswell Park Comprehensive Cancer Center;

21. 21The University of Texas MD Anderson Cancer Center;

22. 22Massachusetts General Hospital Cancer Center;

23. 23UC San Diego Moores Cancer Center;

24. 24Memorial Sloan Kettering Cancer Center;

25. 25Abramson Cancer Center at the University of Pennsylvania;

26. 26The University of Tennessee Health Science Center;

27. 27The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;

28. 28Duke Cancer Institute; and

29. 29National Comprehensive Cancer Network.

Abstract

The NCCN Guidelines for Rectal Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with rectal cancer. These NCCN Guidelines Insights summarize the panel discussion behind recent important updates to the guidelines. These updates include clarifying the definition of rectum and differentiating the rectum from the sigmoid colon; the total neoadjuvant therapy approach for localized rectal cancer; and biomarker-targeted therapy for metastatic colorectal cancer, with a focus on new treatment options for patients with BRAF V600E– or HER2 amplification–positive disease.

Publisher

Harborside Press, LLC

Subject

Oncology

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