Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology

Author:

Abu-Rustum Nadeem R.1,Yashar Catheryn M.2,Arend Rebecca3,Barber Emma4,Bradley Kristin5,Brooks Rebecca6,Campos Susana M.7,Chino Junzo8,Chon Hye Sook9,Crispens Marta Ann10,Damast Shari11,Fisher Christine M.12,Frederick Peter13,Gaffney David K.14,Gaillard Stephanie15,Giuntoli Robert16,Glaser Scott17,Holmes Jordan18,Howitt Brooke E.19,Kendra Kari20,Lea Jayanthi21,Lee Nita22,Mantia-Smaldone Gina23,Mariani Andrea24,Mutch David25,Nagel Christa20,Nekhlyudov Larissa7,Podoll Mirna10,Rodabaugh Kerry26,Salani Ritu27,Schorge John28,Siedel Jean29,Sisodia Rachel30,Soliman Pamela31,Ueda Stefanie32,Urban Renata33,Wethington Stephanie L.15,Wyse Emily34,Zanotti Kristine35,McMillian Nicole36,Espinosa Sara36

Affiliation:

1. Memorial Sloan Kettering Cancer Center

2. UC San Diego Moores Cancer Center

3. O’Neal Comprehensive Cancer Center at UAB

4. Robert H. Lurie Comprehensive Cancer Center of Northwestern University

5. University of Wisconsin Carbone Cancer Center

6. UC Davis Comprehensive Cancer Center

7. Dana-Farber/Brigham and Women’s Cancer Center

8. Duke Cancer Institute

9. Moffitt Cancer Center

10. Vanderbilt-Ingram Cancer Center

11. Yale Cancer Center/Smilow Cancer Hospital

12. University of Colorado Cancer Center

13. Roswell Park Comprehensive Cancer Center

14. Huntsman Cancer Institute at the University of Utah

15. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

16. Abramson Cancer Center at the University of Pennsylvania

17. City of Hope National Medical Center

18. Indiana University Melvin and Bren Simon Comprehensive Cancer Center

19. Stanford Cancer Institute

20. The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute

21. UT Southwestern Simmons Comprehensive Cancer Center

22. The UChicago Medicine Comprehensive Cancer Center

23. Fox Chase Cancer Center

24. Mayo Clinic Comprehensive Cancer Center

25. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine

26. Fred & Pamela Buffett Cancer Center

27. UCLA Jonsson Comprehensive Cancer Center

28. St. Jude Children’s Research Hospital/The University of Tennessee Health Science Center

29. University of Michigan Rogel Cancer Center

30. Mass General Cancer Center

31. The University of Texas MD Anderson Cancer Center

32. UCSF Helen Diller Family Comprehensive Cancer Center

33. Fred Hutchinson Cancer Center

34. Patient Advocate

35. Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute

36. National Comprehensive Cancer Network

Abstract

Vulvar cancer is annually diagnosed in an estimated 6,470 individuals and the vast majority are histologically squamous cell carcinomas. Vulvar cancer accounts for 5% to 8% of gynecologic malignancies. Known risk factors for vulvar cancer include increasing age, infection with human papillomavirus, cigarette smoking, inflammatory conditions affecting the vulva, and immunodeficiency. Most vulvar neoplasias are diagnosed at early stages. Rarer histologies exist and include melanoma, extramammary Paget’s disease, Bartholin gland adenocarcinoma, verrucous carcinoma, basal cell carcinoma, and sarcoma. This manuscript discusses recommendations outlined in the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for treatments, surveillance, systemic therapy options, and gynecologic survivorship.

Publisher

Harborside Press, LLC

Reference130 articles.

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