Author:
Tassi Elena,Noviello Maddalena,De Simone Pantaleo,Lupo-Stanghellini Maria T.,Doglio Matteo,Serio Francesca,Abbati Danilo,Beretta Valeria,Valtolina Veronica,Oliveira Giacomo,Racca Sara,Campodonico Edoardo,Ruggiero Eliana,Clerici Daniela,Giglio Fabio,Lorentino Francesca,Dvir Roee,Xue Elisabetta,Farina Francesca,Oltolini Chiara,Manfredi Francesco,Vago Luca,Corti Consuelo,Bernardi Massimo,Clementi Massimo,Brix Liselotte,Ciceri Fabio,Peccatori Jacopo,Greco Raffaella,Bonini Chiara
Abstract
After allogeneic hematopoietic stem cell transplantation (allo-HSCT), the emergence of circulating Cytomegalovirus(CMV)-specific T cells correlates with protection from CMV reactivation, an important risk factor for non-relapse mortality. However, functional assays measuring CMV-specific cells are time-consuming and often inaccurate at early timepoints. We report results of a prospective single-center non-interventional study which identifies the enumeration of Dextramer-positive CMV-specific lymphocytes as a reliable and early predictor of viral reactivation. We longitudinally monitored 75 consecutive patients for 1 year after allo-HSCT (n=630 samples). The presence of ≥0.5 CMV-specific CD8+ cells//L at day+45 was an independent protective factor from subsequent clinicallyrelevant reactivation in univariate(p
Publisher
Ferrata Storti Foundation (Haematologica)