Outcomes in grade 3B follicular lymphoma: an international study led by the Australasian Lymphoma Alliance

Author:

Barraclough Allison,England James T.,Villa Diego,Wight Joel,Hapgood Greg,Conn Jason,Doo Nicole Wong,Li Eric Wenlong,Gilbertson Michael,Shaw Briony,Bishton Mark J.,Saeed Malik,Ratnasingam Sumita,Abeyakoon Chathuri,Chong Geoff,Wai Shin Hnin,Ku Matthew,Lee Hui-Peng,Fleming Kathryn,Tam Constantine,Douglas Genevieve,Cheah Chan Y.,Ng Zi Yun,Rolfe Tukten,Mills Anthony K,Hamad Nada,Cashman Helen,Gleeson Mary,Narayana Manjunath,Hawkes Eliza A.

Abstract

Grade (G) 3B follicular lymphoma (FL) is a rare FL subtype which exists on a histological continuum between ‘low-grade’ (Grade 1, 2 and 3A FL) and diffuse large B-cell lymphoma (DLBCL) appearing to share features with each. Clinical characteristics and outcomes are poorly understood due to lack of adequate representation in prospective trials and large-scale analyses. We analyzed 157 G3BFL cases from 18 international centers, and two comparator groups; G3AFL (n=302) and DLBCL (n=548). Composite histology with DLBCL or low-grade FL occurred in approximately half of G3BFL cases. With median 5 years follow-up, G3BFL overall (OS; P

Publisher

Ferrata Storti Foundation (Haematologica)

Subject

Hematology

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