Author:
Ramos-Campoy Silvia,Puiggros Anna,Beà Sílvia,Bougeon Sandrine,Larráyoz María José,Costa Dolors,Parker Helen,Rigolin Gian Matteo,Ortega Margarita,Blanco María Laura,Collado Rosa,Salgado Rocío,Baumann Tycho,Gimeno Eva,Moreno Carolina,Bosch Francesc,Calvo Xavier,Calasanz María José,Cuneo Antonio,Strefford Jonathan C.,Nguyen-Khac Florence,Oscier David,Haferlach Claudia,Schoumans Jacqueline,Espinet Blanca
Abstract
Genome complexity has been associated with poor outcome in patients with chronic lymphocytic leukemia (CLL). Previous cooperative studies established five abnormalities as the cut-off that best predicts an adverse evolution by chromosome banding analysis (CBA) and genomic microarrays (GM). However, data comparing risk stratification by both methods are scarce. Herein, we assessed a cohort of 340 untreated CLL patients highly enriched in cases with complex karyotype (CK, 46.5%) with parallel CBA and GM studies. Abnormalities found by both techniques were compared. Prognostic stratification in three risk groups based on genomic complexity [0-2, 3-4 and ≥5 abnormalities] was also analyzed. No significant differences in the percentage of patients classified into each category were detected, but only a moderate agreement was observed between methods when focusing in individual cases (κ=0.507; p
Publisher
Ferrata Storti Foundation (Haematologica)
Cited by
16 articles.
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