Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells

Abstract

It is of interest to report the chemotherapeutic (drug target based) potential of n-hexane Cayratia trifolia L. (C.trifolia) extract on A2780 cell lines. mRNA and protein expression analysis of the human chemokine receptor (CXCR4) and human epidermal growth factor receptors-2 (HER2) were studied using RT-PCR analysis and western blot analysis. The results show significant cell growth inhibition with minimal IC50 values of 46.25 ą 0.42 micro g/mL against A2780 cell lines. mRNA and protein expression were considerably reduced in C. trifolia treated A2780 cell lines for further consideration as a chemotherapeutic agents.