Oleic Acid-PVA Based Amphiphilic Polymer Micelles for Vitamin D Encapsulation-Reference-Cited by-同舟云学术

Oleic Acid-PVA Based Amphiphilic Polymer Micelles for Vitamin D Encapsulation

Published:2023-11-11 Issue:4 Volume:10 Page:1055-1062
ISSN:2149-0120
Container-title:Journal of the Turkish Chemical Society Section A: Chemistry
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Author:

BİRTANE Hatice¹^ORCID

Affiliation:

1. Marmara Üniversitesi

Abstract

In this study, oleic acid-PVA based amphiphilic polymer micelles were prepared for vitamin D encapsulation. The amphiphilic polymer encapsulations were characterized using Fourier transformed infrared spectroscopy (FTIR) and nuclear magnetic resonance spectroscopy (1H-NMR). The goal of the study was to create micelles by using a lipophilic and biocompatible polymer. An oleic acid-substituted polyvinyl alcohol polymer was created through an acidic esterification reaction. The chemical structure of the polymer was disclosed by FTIR. To calculate the polymer's substitution ratio, 1H-NMR was used. Micellization was used to encapsulate vitamin D. Scanning electron microscope (SEM) analysis was used to determine the crucial micelle concentration and the size of the oleic acid-modified PVA. Ultraviolet–visible (UV) spectroscopy was used to analyze the release of vitamin D at various pH levels. As a result, vitamin D can be enclosed in PVA polymer that has been substituted with oleic acid.

Publisher

The Turkish Chemical Society

Subject

General Chemistry

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