Association of polymorphic variants of hemostatic system genes with the course of COVID-19

Author:

Nikolaeva Lyudmila I.ORCID,Stuchinskaya Maya D.ORCID,Dedova Anna V.ORCID,Nadezhda Shevchenko G.ORCID,Khlopova Irina N.ORCID,Kruzhkova Irina S.ORCID,Merkulova Lilya N.ORCID,Kisteneva Lidya B.ORCID,Kolobukhina Lyudmila V.ORCID,Mukasheva Evgenya A.ORCID,Krasnoslobodtsev Kirill G.ORCID,Trushakova Svetlana V.ORCID,Krepkaya Anastasia S.ORCID,Kuprianov Victor V.ORCID,Nikitenko Natalia A.ORCID,Khadorich Elizaveta A.ORCID,Burmistrov Egor M.ORCID,Tyurin Igor N.ORCID,Antipyat Natalia A.ORCID,Burtseva Elena I.ORCID

Abstract

Introduction. COVID-19 is characterized by a varied clinical course. The aim of the work was to identify associations of SNPs of hemostatic system genes with COVID-19. Materials and methods. DNA was isolated from patients (n=117) and healthy participants (n=104). All infected patients were divided into 3 groups, depending on disease severity assessment, which was appreciated by NEWS2. Another group consisted of participants, who had asymptomatic infection in the past. Determination of SNPs of the genes FGB (-455 G/A), FII (20210 G/A), FV (1691 G/A), FVII (10976 G/A), FXIIIA1 (103 G/T), ITGA2 (807 C/T), ITGB3 (1565 T/C), SERPINE1 (-675 5G/4G) were performed by PCR using the “Genetics of Hemostasis” kit (“DNA-Technology”, Russia). Results. In analyzed SNPs, no significant differences were detected between the group of infected patients and healthy participants. But significant association was revealed in gene SERPINE1 (-675 5G/4G), when patient groups, differing in the disease severity, were analyzed relative to the group of participants with asymptomatic infection (p=0.0381; p=0 .0066; p=0.0009). It was found, that as COVID-19 severity scores increased, the proportion of 5G allele of gene SERPINE1 decreased, and the proportion of the 4G allele increased (p=0.005; p=0.009; p=0.0005). Similar processes were observed for genotypes 5G/5G and 4G/4G. Discussion. The gene SERPINE1 (-675 5G/4G) is associated with the severity of COVID-19. Conclusion. For the first time, it was discovered that 5G/5G genotype of gene SERPINE1 (-675 5G/4G) can be a marker of a milder course of COVID-19, and the 4G/4G genotype as a more severe one.

Publisher

Central Research Institute for Epidemiology

Subject

Infectious Diseases,Virology,General Medicine

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