The role of Epstein-Barr viral infection and hepatitis B and C in liver pathology

Author:

Solomay T. V.1ORCID,Semenenko T. A.2ORCID,Ivanova M. Yu.3ORCID

Affiliation:

1. Interregional Department № 1

2. National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F.Gamaleya; I.M.Sechenov First Moscow State Medical University (Sechenov University)

3. I.M.Sechenov First Moscow State Medical University (Sechenov University)

Abstract

A review of scientific literature data on clinical and epidemiological characterization of viral hepatitis B, C and Epstein-Barr viral infection is presented. Scopus, Web of Science, MedLine, The Cochrane Library, PubMed, CyberLeninka, RSCI databases were used to find the necessary literature. It was shown that Epstein-Barr virus along with hepatitis B and C viruses plays a significant role in the development of virus-mediated autoimmune liver diseases, as well as other organs (intestine, heart, kidneys, thyroid gland, etc.). The similarity of these nosologies is also evident in the nature of the course of the disease: the presence of a primary infection in a manifest or latent form, with possible subsequent chronization of the process and its periodic reactivation. Wide distribution of pathogens in the human population determines the possibility of mixed infections with Epstein-Barr virus and hepatitis B and C viruses, however, this problem has not been adequately described in the scientific literature. The review suggests that the role of Epstein-Barr virus in the development of liver diseases and extrahepatic pathology should not be ignored, and the combination of this pathogen with hepatitis B and C viruses required further in-depth studies.

Publisher

Central Research Institute for Epidemiology

Subject

Infectious Diseases,Virology,General Medicine

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