MOLECULAR BIOLOGY OF HEPATITIS B VIRUS AND IMMUNOPATHOGENESIS OF CHRONIC VIRAL HEPATITIS B

Author:

Balmasova I. P.1,Sepiashvili R. I.1,Malova E. S.1

Affiliation:

1. Evdokimov Moscow State Medical Stomatological University, Russian University of Peoples’ Friendship

Abstract

Hronic hepatitis B belongs to a category of socially significant diseases due to its wide abundance in the world and high frequency of unfavourable outcomes of this disease. Features of interaction of hepatitis B virus with human immune system, accompanying development of mechanisms of escape from immunological control, is the basis of development of chronic hepatitis B. Molecular-biological features of hepatitis B virus are the basis of the indicated mechanisms, and the content of this review is their examination. Herewith, stages of immunopathogenesis of this disease is the basis of characteristics of interaction of viral proteins with cells of immune system, and isolation of those is accepted in contemporary foreign literature.

Publisher

Central Research Institute for Epidemiology

Subject

General Medicine

Reference58 articles.

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2. Cepiashvili RI.,Balmasova I.P. Immunnye sinapsy:ot teorii k klinicheskoi praktike. Molekulyarnaya meditsina. 2008, 1: 14-22.

3. Sepiashvili RI.,Balmasova I.P. Estestvennye killery i biogennye aminy: parakrinnaya regulyatsiya v immunnoi sisteme. Ross. fiziol. zhurn. im. I.M.Sechenova. 2005, 8: 927.

4. Araki K., Miyazaki J., Hino O. et al. Expression and replication of hepatitis B virus genome in transgenic mice. Proc. Natl. Acad. Sci. USA. 1989, 86 (1): 207-211.

5. Balmasova I.P, Yushchuk N.D., Mynbaev O.A. et al. Immunopathogenesis of chronic hepatitis B. World. J. Gastroenterol. 2014, 20 (39): 14156-14171.

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