Affiliation:
1. Rostov State Medical University
Abstract
Pathogenicity factors of Corynebacterium non diphtheriae - pili, microcapsule, cell wall, pathogenicity enzymes, toxins, that determine the ability of microorganisms to consequentially interact with epithelium of entry gates of the organism, replicate in vivo, overcome cell and humoral mechanisms of protection, are examined in the review. Particular attention in the paper is given to species of non-diphtheria corynebacteria, that are pathogenic for human and able to produce toxins - Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. Mechanisms of expression regulation of PLD-exotoxins, its interaction with immune system cells are described.
Publisher
Central Research Institute for Epidemiology
Reference42 articles.
1. Kharseeva G.G., Alieva A.A. Adgeziya Corynebacterium diphtheriae: rol' poverkhnostnykh struktur i mekhanizm formirovaniya. Zhurn. mikrobiol. 2014, 4: 109-117.
2. Alteri C.J., Xicohtencatl-Cortes J., Hess S. et al. Mycobacterium tuberculosis produces pili during human infection. Proc. Natl. Acad. Sci. USA. 2007, 104: 5145-5150.
3. Anantharaman V., Aravind L. Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes. Genome Biology. 2003, 4 (2): 2-6.
4. Aquino de Sa Mda C., Gouveia G.V., Krewer Cda C. et al. Distribution of PLD and Fag A, B, C and Dgenes in Corynebacterium pseudotuberculosis isolates from sheep and goats with caseus lymphadenitis. Genet Mol. Biol. 2013, 36 (2): 265-268.
5. Baird G.J., Fontaine M.C.Corynebacterium pseudotuberculosis and its role in ovine caseous lymphadenitis. J. Comp. Pathol. 2007, 137: 179-210.