A modern view of pro-/eukaryote interactions in the human body as the basis for development of next-generation probiotics-Reference-Cited by-同舟云学术

A modern view of pro-/eukaryote interactions in the human body as the basis for development of next-generation probiotics

Published:2020-09-02 Issue:4 Volume:97 Page:346-355
ISSN:2686-7613
Container-title:Journal of microbiology, epidemiology and immunobiology
language:
Short-container-title:Zhurnal mikrobiologii, èpidemiologii i immunobiologii

Author:

Mikhailova Natalia A.¹^ORCID,Voevodin Dmitry A.¹^ORCID,Lazarev Sergey A.¹^ORCID

Affiliation:

1. Mechnikov Research Institute for Vaccines and Sera

Abstract

Multicellular organisms and the saprophytic flora form complex, highly integrated chimeric systems (associative symbioses, metaorganisms) characterized by interplay between pro- and eukaryotic components. To be able to interact symbiotically microorganisms (MO) need a whole body.When grown on artificial media for a long time, symbiotic MO have to adapt to the artificial environment and gradually, though reversibly, lose their ability of associative interaction with the human body, thus causing a decrease in the therapeutic efficacy of MO-derived probiotic products. To increase the therapeutic activity of probiotic MO, they must be functionally rehabilitated.A pathological process induces development of a secondary metabolic dysbiosis; as a result, changes in the regulatory processes of an individual interfere with the restoration of the normal microflora. Therefore, functional rehabilitation of probiotic MO must take place during cultivation, while the cultivation process must replicate the whole-body conditions.

Publisher

Central Research Institute for Epidemiology

Subject

General Medicine

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