Affiliation:
1. State Research Center of Virology and Biotechnology «Vector»
2. Central Research Institute of Epidemiology;
State Institute of Occupational Health
3. Central Research Institute of Epidemiology
4. Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing;
Russian Medical Academy of Postgraduate Education
Abstract
Ebola virus disease is dangerous viral infection, occurring in the form of hemorrhagic fever, characterized by acute clinical symptoms and high mortality rate due to multiple organ failure. Ebola virus natural foci are located in forested areas of the central and western parts of Africa. It was believed for many years, the incidence of Ebola virus disease has been sporadic and the burden of it is true only in endemic areas. However, the unprecedented Ebola epidemic caused by Zaire virus in 2013 — 2016, has significantly changed our understanding of this disease and the patterns of its distribution. We have also identified weaknesses in the organization of anti-epidemic measures, the effectiveness of which was not very effective at the onset of the epidemic, in particular due to weak development of in vitro diagnostics (IVD). However, during the elimination of the epidemic in West Africa, anti-epidemic system has been modified substantially, largely due to quickly developed IVD kits. This review is devoted to analysis of trends in IVD for Ebola virus disease based on the experience obtained in the course of the West-African epidemic in 2013 — 2016.
Publisher
Central Research Institute for Epidemiology
Reference48 articles.
1. P'yankov S.A., P'yankov O.V., Naidenova E.V., Agafonov A.P., Boiro M.Y., Solodkii V.V., Zaikovskaya A.V., Maksimov N.L., Marennikova S.S., Bocharov E.F., Ofitserov V.I., Lopatin A.A., Shcherbakova S.A., Kutyrev V.V., Mikheev V.N., Demina Yu.V. Opyt ispol'zovaniya metoda IFA dlya vyyavleniya antitel k virusu Ebola pri rabote brigady SPEB v respublike Gvineya. Problemy osobo opasnykh virusnykh infektsii. 2016, 3: 71-75.
2. RU № RZN 2013/1322 na meditsinskoe izdelie «Nabor reagentov dlya amplifikatsii kDNK virusa Ebola (Zair, Sudan) s gibridizatsionno-fluorestsentnoi detektsiei v rezhime real'nogo vremeni (dlya priborov Rotor Gene 6000) «Vektor PTsR RV-Ebola-RG» po TU 9398-017-05664012-2011.
3. Ternovoi V.A., Sementsova A.O., Chub E.V., P'yankov O.V., Loktev V.B., Agafonov A.P. Vysokoeffektivnoe khMAP-mul'tepleksirovanie dlya obnaruzheniya i identifikatsii gemorragicheskikh likhoradok, vklyuchaya Ebola. Problemy osoboopasnykh infektsii. 2015, 3: 94-97.
4. Shchelkanov M.Yu., Magassuba N.F., Dedkov V.G., Shipulin G.A., Galkina I.V., Popova A.Yu., Maleev V.V. Prirodnyi rezervuar filovirusov i tipy svyazannykh s nimi epidemicheskikh vspyshek na territorii Afriki. Vestnik RAMN. 2017, 72 (2): 112-119. doi: 10.15690/vramn803.
5. Boisen M.L., Cross R.W., Hartnett J.N. et al. Field validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection. J. Infect. Dis. 2016, 214 (Suppl. 3): S203-S209.