Abstract
The review summarizes current literature data on the main structures and components of the tularemia microbe responsible for adaptation to the warm-blooded host macroorganism (susceptible animals, humans). According to scientific data, the successful survival of Francisella tularensis under stress conditions requires the interaction of all cellular structures of the microbe. Despite active research carried out in the field of studying the determinants and mechanisms of F. tularensis resistance, the reason for the high adaptive capacity with low variability of the tularemia pathogen has not been established. These studies are important for understanding the mechanisms of persistence and virulence of F. tularensis, as well as for further development of vaccines and diagnostic tests.
Publisher
Central Research Institute for Epidemiology
Subject
General Medicine,Medicine (miscellaneous)
Reference47 articles.
1. Попова А.Ю., Мефодьев В.В., Степанова Т.Ф., Ежлова Е.Б., Демина Ю.В., Марченко А.Н. Эпидемиология и профилактика туляремии на эндемичных территориях России: монография. Тюмень; 2016.
2. Олсуфьев Н.Г., Дунаева Т.Н. Природная очаговость, эпидемиология и профилактика туляремии. М.: Медицина; 1970.
3. Hennebique A., Peyroux J., Brunet C., Martin A., Henry T., Knezevic M., et al. Amoebae can promote the survival of Francisella species in the aquatic environment. Emerg. Microbes Infect. 2021; 10(1): 277–90. https://doi.org/10.1080/22221751.2021.1885999
4. Мещерякова И.С. Туляремия. В кн.: Природная очаговость болезней: Исследования института им. Н.Ф. Гамалеи РАМН. М.; 2003: 137–60.
5. Telford S.R. 3rd, Goethert H.K. Ecology of Francisella tularensis. Annu. Rev. Entomol. 2020; 7(65): 351–72. https://doi.org/10.1146/annurev-ento-011019-025134