COGNITIVE AXIS OF AGING: INFLAMMATION - MICROBIOTA OF SMALL INTESTINE

Abstract

Aim. Detect connection between cognitive dysfunction in senior people with systemic infection profile and small intestine microbiota structure. Materials and methods. 42 senior individuals were included into the study All the examined have been divided into 2 groups based on the results of psychic status: 20 individuals with moderate cognitive disorders - «active longevity» group and 22 individuals with pronounced cognitive deficiency - «mercy» group. Systemic inflammation status and structure and quantitative composition of microbiota of small intestine was determined in all the senior individuals using gas chromatography mass-spectrometry of microbial markers. Results. Interconnection between systemic level of cytokines and microbiota structure of small intestine in senior people with various cognitive status was determined. Significant correlations between levels of pro-inflammatory cytokine IL-6 in blood plasma and quantity of Propionibacterium jensenii, Moraxella spp., Bacillus cereus and Fusobacterium spp. in small intestine and the degree of cognitive failure were detected for the first time. Conclusion. The parameters obtained could be used as predictive biomarkers of cognitive dysfunction in senior people.