LICENSED ANTHRAX VACCINES AND EXPERIMENTAL PREPARATIONS AT THE STAGE OF CLINICAL TRIALS-Reference-Cited by-同舟云学术

LICENSED ANTHRAX VACCINES AND EXPERIMENTAL PREPARATIONS AT THE STAGE OF CLINICAL TRIALS

Published:2017-08-28 Issue:4 Volume: Page:112-126
ISSN:0372-9311
Container-title:Journal of microbiology epidemiology immunobiology
language:
Short-container-title:Zhurnal Mikrobiologii Epidemiologii i Immunobiologii

Author:

Mikshis N. I.¹,Popova P. Yu.¹,Semakova A. P.¹,Kutyrev V. V.¹

Affiliation:

1. Russian Research for Plague Control Institute «Microb»

Abstract

High pathogenicity of anthrax agent combined with unique insensitivity of its spore forms to environmental stresses class it among extremely dangerous biological agents. Registered and effectively used anthrax vaccines made invaluable contribution to the improvement of epidemiological situation around the world. Nevertheless, neglect of non-specific prophylaxis may result in dramatic scenarios and require large-scale measures on rectification of the consequences. Efforts on the development of next-generation vaccines are aimed at safety build-up, decrease in frequency of administration, and enhancement of manufacturing technologies. The review contains the key information on licensed anthrax vaccines designed for medical use, both in the territory of the Russian Federation and abroad. Among multiple experimental developments emphasized have been preparations manufactured by various biopharmaceutical companies in compliance with GMP standards, at different phases of clinical trials in 2016.

Publisher

Central Research Institute for Epidemiology

Subject

General Medicine

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