Can auditory brain stem response accurately reflect the cochlear function?

Author:

Ding Dalian123,Zhang Jianhui2,Li Wenjuan4,Li Dong4,Yu Jintao5,Wu Xuewen6,Qi Weidong7,Liu Fang8,Jiang Haiyan1,Shi Haibo3,Sun Hong6,Li Peng9,Huang Weiluo10,Salvi Richard1

Affiliation:

1. Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York

2. The Third People’s Hospital of Chengdu, Chengdu, China

3. Shanghai Six People’s Hospital, Shanghai Jiao Tong University, Shanghai, China

4. Department of Otolaryngology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

5. Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

6. Xiangya Hospital, Central South University, Changsha, China

7. Huashan Hospital, Fudan University, Shanghai, China

8. Beijing Hospital and National Center of Gerontology, Department of Otolaryngology, Beijing, China

9. The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

10. YouHear Academy, Guangzhou, China

Abstract

Auditory brain stem response (ABR) is more commonly used to evaluate cochlear lesions than cochlear compound action potential (CAP). In a noise-induced cochlear damage model, we found that the reduced CAP and enhanced ABR caused the threshold difference. In a unilateral cochlear destruction model, a shadow curve of the ABR from the contralateral healthy ear masked the hearing loss in the destroyed ear.

Funder

NIHR01

Foundation of Science and Technology Commission of Shanghai Municipality

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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