Development of neuronal timescales in human cortical organoids and rat hippocampus dissociated cultures-Reference-Cited by-同舟云学术

Development of neuronal timescales in human cortical organoids and rat hippocampus dissociated cultures

Published:2024-09-01 Issue:3 Volume:132 Page:757-764
ISSN:0022-3077
Container-title:Journal of Neurophysiology
language:en
Short-container-title:Journal of Neurophysiology

Author:

Martin-Burgos Blanca¹^ORCID,McPherson Trevor Supan¹^ORCID,Hammonds Ryan²³,Gao Richard²^ORCID,Muotri Alysson R.⁴⁵,Voytek Bradley²³¹⁶^ORCID

Affiliation:

1. Neurosciences Graduate Program, University of California, San Diego, La Jolla, California, United States

2. Department of Cognitive Science, University of California, San Diego, La Jolla, California, United States

3. Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, California, United States

4. Department of Pediatrics/Rady Children’s Hospital San Diego, School of Medicine, University of California, San Diego, La Jolla, California, United States

5. Department of Cellular & Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, California, United States

6. Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, California, United States

Abstract

Neuronal timescales describe the persistence of activity within a network of neurons. Timescales were found to fluctuate with development in two model systems. In cortical organoids timescales increased, peaked, and then decreased throughout development; in rat hippocampal dissociated cultures timescales decreased over development. These distinct developmental models overlap to highlight a critical window in which timescales lengthen and contract, potentially indexing changes in the information capacity of neuronal systems.

Funder

California Institute for Regenerative Medicine

HHS | NIH | National Institute of General Medical Sciences

U.S. Department of Defense

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/jn.00135.2024

Reference34 articles.

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