Affiliation:
1. Experimental and Clinical Research Center and Max-Delbrück Center for Molecular Medicine and Charité Medical Faculty, Berlin, Germany; and Department of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee
Abstract
Stimulating antibodies against G-protein-coupled receptors, including the β1- and β2-adrenergic receptors, the α1-adrenergic receptor, and the angiotensin II AT1 receptor, have been described, as well as activating antibodies directed at the platelet-derived growth factor receptor tyrosine kinase. Their existence and actions appear to be established. Lacking are mechanistic studies of receptor activation and translational studies to document receptor-stimulating antibodies as worthwhile therapeutic targets.
Publisher
American Physiological Society
Cited by
26 articles.
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