No Rest for the Weary: Diastolic Calcium Homeostasis in the Normal and Failing Myocardium-Reference-Cited by-同舟云学术

No Rest for the Weary: Diastolic Calcium Homeostasis in the Normal and Failing Myocardium

Published:2012-10 Issue:5 Volume:27 Page:308-323
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Louch William E.¹,Stokke Mathis K.¹,Sjaastad Ivar¹,Christensen Geir¹,Sejersted Ole M.¹

Affiliation:

1. Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway; and KG Jebsen Cardiac Research Center and Center for Heart Failure Research, University of Oslo, Oslo, Norway

Abstract

Following contraction of the heart, efficient relaxation (diastole) is essential for refilling the ventricles with blood. This review describes how ventricular relaxation is controlled by Ca2+ homeostasis in cardiac muscle cells and how alterations in Ca2+ cycling affect diastolic function in the normal and failing heart. These discussions illustrate that the diastolic phase is not simply a period of rest but rather involves highly regulated and dynamic Ca2+ fluxes.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00021.2012

Reference96 articles.

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