Impact of Maternal Obesity on Fetal Programming of Cardiovascular Disease-Reference-Cited by-同舟云学术

Impact of Maternal Obesity on Fetal Programming of Cardiovascular Disease

Published:2015-05 Issue:3 Volume:30 Page:224-231
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Roberts Victoria H. J.¹,Frias Antonio E.¹²,Grove Kevin L.¹

Affiliation:

1. Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, Oregon; and

2. Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon

Abstract

The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to maternal consequences of obesity during pregnancy and the subsequent impact on fetal cardiovascular development.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00021.2014

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