Interplay of the Circadian Clock and Endothelin System-Reference-Cited by-同舟云学术

Interplay of the Circadian Clock and Endothelin System

Published:2021-01-01 Issue:1 Volume:36 Page:35-43
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Douma Lauren G.¹²,Barral Dominique¹,Gumz Michelle L.¹²³⁴

Affiliation:

1. Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida

2. Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida

3. Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida

4. Center for Integrative Cardiovascular and Metabolic Disease, University of Florida, Gainesville, Florida

Abstract

The peptide hormone endothelin-1 and its receptors are linked to several disease states. Pharmacological inhibition of this pathway has proven beneficial in pulmonary hypertension, yet its potential in other disease states remains to be realized. This review considers an often understudied aspect of endothelin biology, circadian rhythm regulation and how understanding the intersection between endothelin signaling and the circadian clock may be leveraged to realize the potential of endothelin-based therapeutics.

Funder

American Heart Association

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute on Aging

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiol.00021.2020

Reference74 articles.

1. Collecting duct–specific knockout of endothelin-1 causes hypertension and sodium retention