The Mammalian Urine Concentrating Mechanism: Hypotheses and Uncertainties-Reference-Cited by-同舟云学术

The Mammalian Urine Concentrating Mechanism: Hypotheses and Uncertainties

Published:2009-08 Issue:4 Volume:24 Page:250-256
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Layton Anita T.¹,Layton Harold E.¹,Dantzler William H.²,Pannabecker Thomas L.²

Affiliation:

1. Department of Mathematics, Duke University, Durham, North Carolina; and

2. Department of Physiology, College of Medicine, University of Arizona, Tuscon, Arizona,

Abstract

The urine concentrating mechanism of the mammalian kidney, which can produce a urine that is substantially more concentrated than blood plasma during periods of water deprivation, is one of the enduring mysteries in traditional physiology. Owing to the complex lateral and axial relationships of tubules and vessels, in both the outer and inner medulla, the urine concentrating mechanism may only be fully understood in terms of the kidney’s three-dimensional functional architecture and its implications for preferential interactions among tubules and vessels.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00013.2009

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