Exercise-Pharmacology Interactions: Metformin, Statins, and Healthspan

Author:

Miller Benjamin F.123ORCID,Thyfault John P.456

Affiliation:

1. Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma

2. Oklahoma Nathan Shock Center for Aging, Oklahoma City, Oklahoma

3. Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

4. Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas

5. Research Service, Kansas City VA Medical Center, Kansas City, Missouri

6. Center for Children’s Healthy Lifestyle and Nutrition, Children’s Mercy Hospital, Kansas City, Missouri

Abstract

There is an increased focus on treatments to extend the healthspan. There is solid evidence that exercise extends the healthspan, but other treatments, such as metformin and statins, are also gaining traction. If metformin and statins will be used to prolong healthspan, we must understand their effects in those free of disease and in combination with exercise.

Funder

Office of Extramural Research, National Institutes of Health

Center for Integrated Healthcare, U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology

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