Circulating Cell-Free Mitochondrial DNA in Pregnancy-Reference-Cited by-同舟云学术

Circulating Cell-Free Mitochondrial DNA in Pregnancy

Published:2022-07-01 Issue:4 Volume:37 Page:187-196
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Bradshaw Jessica L.¹^ORCID,Cushen Spencer C.¹²,Phillips Nicole R.³,Goulopoulou Styliani¹⁴^ORCID

Affiliation:

1. Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas

2. Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, Texas

3. Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas

4. Lawrence D. Longo MD Center for Perinatal Biology, Loma Linda University, Loma Linda, California

Abstract

Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss the temporal changes of ccf-mtDNA during pregnancy and its potential contribution to adverse pregnancy outcomes in pregnancy complications.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

American Heart Association

Texas Alzheimer’s Research and Care Consortium

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiol.00037.2021

Reference104 articles.