How Do Kidneys Adapt to a Deficit or Loss in Nephron Number?-Reference-Cited by-同舟云学术

How Do Kidneys Adapt to a Deficit or Loss in Nephron Number?

Published:2019-05-01 Issue:3 Volume:34 Page:189-197
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Fattah Hadi¹²,Layton Anita³⁴,Vallon Volker¹²

Affiliation:

1. Departments of Medicine and Pharmacology, Division of Nephrology and Hypertension, University of California San Diego, San Diego, California

2. Department of Veterans Affairs, San Diego Healthcare System, San Diego, California

3. Department of Applied Mathematics and School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

4. Departments of Mathematics, Biomedical Engineering, and Medicine, Duke University, Durham, North Carolina

Abstract

A deficit or loss in the number of nephrons, the functional unit of the kidney, can induce compensatory growth and hyperfunction of remaining nephrons. An increase in single nephron glomerular filtration rate (SNGFR) aims to compensate but may be deleterious in the long term. The increase in SNGFR is determined by the dynamics of nephron loss, total remaining GFR, the body’s excretory demand, and the functional capacity to sustain single nephron hyperfunction.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Canada 150 Research Chairs

U.S. Department of Veterans Affairs (VA)

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00052.2018

Reference53 articles.

1. The emerging role of MRI in quantitative renal glomerular morphology