Pulmonary Surfactant Pathophysiology: Current Models and Open Questions-Reference-Cited by-同舟云学术

Pulmonary Surfactant Pathophysiology: Current Models and Open Questions

Published:2010-06 Issue:3 Volume:25 Page:132-141
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Perez-Gil Jesús¹,Weaver Timothy E.²

Affiliation:

1. Department Bioquímica, Faculty Biología, Universidad Complutense, Madrid, Spain; and

2. Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio

Abstract

Pulmonary surfactant is an essential lipid-protein complex that stabilizes the respiratory units (alveoli) involved in gas exchange. Quantitative or qualitative derangements in surfactant are associated with severe respiratory pathologies. The integrated regulation of surfactant synthesis, secretion, and metabolism is critical for air breathing and, ultimately, survival. The goal of this review is to summarize our current understanding and highlight important knowledge gaps in surfactant homeostatic mechanisms.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00006.2010

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5. Mitochondrial Processing of Newly Synthesized Steroidogenic Acute Regulatory Protein (StAR), but Not Total StAR, Mediates Cholesterol Transfer to Cytochrome P450 Side Chain Cleavage Enzyme in Adrenal Cells

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