GLP-1-Based Strategies: A Physiological Analysis of Differential Mode of Action-Reference-Cited by-同舟云学术

GLP-1-Based Strategies: A Physiological Analysis of Differential Mode of Action

Published:2014-03 Issue:2 Volume:29 Page:108-121
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Burcelin Rémy¹,Gourdy Pierre¹²,Dalle Stéphane³

Affiliation:

1. INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, Toulouse, France;

2. Service de Diabétologie, Maladies Métaboliques et Nutrition, CHU de Toulouse, Toulouse, France; and

3. INSERM, U661, Institut de Génomique Fonctionnelle, CNRS, UMR-5203, Universités de Montpellier 1 & 2, Montpellier, France

Abstract

DPP4 inhibitors and GLP-1 receptor agonists used in incretin-based strategies treat Type 2 diabetes with different modes of action. The pharmacological blood GLP-1R agonist concentration targets pancreatic and some extrapancreatic GLP-1R, whereas DPP4i favors the physiological activation of the gut-brain-periphery axis that could allow clinicians to adapt the management of Type 2 diabetes, according to the patient's pathophysiological characteristics.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00009.2013

Reference177 articles.

1. Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease

2. The inhibitory effects of peripheral administration of peptide YY3–36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal–brainstem–hypothalamic pathway

3. Electrophysiological study of hepatic vagal projection to the medulla

4. Convergence of hepatoportal glucose-sensitive afferent signals to glucose-sensitive units within the nucleus of the solitary tract

5. Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Anti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications;Therapeutic Advances in Endocrinology and Metabolism;2024-01

3. Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases;International Journal of Molecular Sciences;2022-08-24

4. A Novel Bacterium, Butyricimonas virosa, Preventing HFD-Induced Diabetes and Metabolic Disorders in Mice via GLP-1 Receptor;Frontiers in Microbiology;2022-05-17

5. Deciphering the Neuroprotective Role of Glucagon-like Peptide-1 Agonists in Diabetic Neuropathy: Current Perspective and Future Directions;Current Protein & Peptide Science;2021-04-06