Affiliation:
1. Department of Pathology, OB/GYN and Institute of Cancer Genetics, Columbia University Medical Center, New York, New York
Abstract
Wnt growth factors function via Frizzled receptors to affect cellular proliferation, differentiation, apoptosis, and migration. Wnt/Frizzled signaling is now linked to human hereditary disorders with retinal vascular defects, implicating Wnts as angiogenic factors. Here, we discuss Wnts and a novel Frizzled ligand, Norrin, in physiological and pathological angiogenesis.
Publisher
American Physiological Society
Cited by
75 articles.
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