Protein Homeostasis at the Plasma Membrane-Reference-Cited by-同舟云学术

Protein Homeostasis at the Plasma Membrane

Published:2014-07 Issue:4 Volume:29 Page:265-277
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Apaja Pirjo M.¹,Lukacs Gergely L.¹²

Affiliation:

1. Department of Physiology and Research Group Focused on Protein Structure (GRASP), McGill University, Montreal, Quebec, Canada; and

2. Department of Biochemistry, McGill University, Montreal, Quebec, Canada

Abstract

The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets conformationally damaged membrane proteins for lysosomal/vacuolar degradation. Here, we provide an overview of emerging aspects of the underlying mechanisms of PM QC that fulfill a critical role in preserving cellular protein homeostasis in health and diseases.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00058.2013

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