Protons and Ca2+: Ionic Allies in Tumor Progression?

Author:

Glitsch Maike1

Affiliation:

1. Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, United Kingdom

Abstract

Ion channels and G-protein-coupled receptors (GPCRs) play a fundamental role in cancer progression by influencing Ca2+influx and signaling pathways in transformed cells. Transformed cells thrive in a hostile environment that is characterized by extracellular acidosis that promotes the pathological phenotype. The pathway(s) by which extracellular protons achieve this remain unclear. Here, a role for proton-sensing ion channels and GPCRs as mediators of the effects of extracellular protons in cancer cells is discussed.

Publisher

American Physiological Society

Subject

Physiology

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