Affiliation:
1. Department of Cardiovascular Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, Germany
Abstract
The giant muscle protein titin, the “backbone” of the sarcomere, harbors a complex molecular spring whose stiffness is variably tuned in health and disease. Titin is increasingly recognized as a crucial integrator of diverse myocyte signaling pathways. The titin-associated signalosome includes hotspots of protein-protein interactions important for the regulation of protein quality-control mechanisms, hypertrophic gene activation, and mechanosensing.
Publisher
American Physiological Society
Cited by
104 articles.
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