The pH of the Secretory Pathway: Measurement, Determinants, and Regulation-Reference-Cited by-同舟云学术

The pH of the Secretory Pathway: Measurement, Determinants, and Regulation

Published:2004-08 Issue:4 Volume:19 Page:207-215
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Paroutis Paul¹,Touret Nicolas¹,Grinstein Sergio¹

Affiliation:

1. Cell Biology Program, Hospital for Sick Children, Toronto M5G 1X8, and Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Abstract

The luminal pH of the secretory pathway plays a critical role in the posttranslational modification and sorting of proteins and lipids. The pH of each one of the organelles that constitute the pathway is unique, becoming more acidic as the biosynthetic cargo approaches its destination. The methods used for measurement of pH in the secretory pathway, its determinants, and its regulation are the subjects of this review.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00005.2004

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