Glucose Lowering Strategies for Cardiac Benefits: Pathophysiological Mechanisms-Reference-Cited by-同舟云学术

Glucose Lowering Strategies for Cardiac Benefits: Pathophysiological Mechanisms

Published:2018-05-01 Issue:3 Volume:33 Page:197-210
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Bajaj Harpreet S.¹²^ORCID,Zinman Bernard²³⁴

Affiliation:

1. LMC Diabetes & Endocrinology, Brampton, Ontario, Canada

2. Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada

3. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

4. Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada

Abstract

Recent trials in Type 2 diabetes (T2D) have shown cardiovascular benefits with specific GLP-1 receptor agonists and SGLT2 inhibitors. We discuss the landscape of outcome trials in T2D from a pathophysiology viewpoint, review current knowledge gaps in underlying mechanisms, propose a caloric fuel routing hypothesis, and highlight areas of future research.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00004.2018

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