A Cool Channel in Cold Transduction-Reference-Cited by-同舟云学术

A Cool Channel in Cold Transduction

Published:2011-08 Issue:4 Volume:26 Page:273-285
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Latorre Ramón¹,Brauchi Sebastián²,Madrid Rodolfo³,Orio Patricio¹

Affiliation:

1. Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile;

2. Instituto de Fisiología, Universidad Austral de Chile, Valdivia, Chile; and

3. Laboratorio de Neurociencia, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile

Abstract

Transient receptor potential melastatin 8 (TRPM8), a calcium-permeable cation channel activated by cold, cooling compounds and voltage, is the main molecular entity responsible for detection of cold temperatures in the somatosensory system. Here, we review the biophysical properties, physiological role, and near-membrane trafficking of this exciting polymodal ion channel.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00004.2011

Reference138 articles.

1. Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8

2. TRPM8 Activation by Menthol, Icilin, and Cold Is Differentially Modulated by Intracellular pH

3. Modulation of the Cold-Activated Channel TRPM8 by Lysophospholipids and Polyunsaturated Fatty Acids

4. Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain

5. TRPM8, a Sensor for Mild Cooling in Mammalian Sensory Nerve Endings

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