Physiological Roles of the TRPM4 Channel Extracted from Background Currents-Reference-Cited by-同舟云学术

Physiological Roles of the TRPM4 Channel Extracted from Background Currents

Published:2010-06 Issue:3 Volume:25 Page:155-164
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Guinamard Romain¹,Demion Marie²,Launay Pierre³

Affiliation:

1. Groupe Coeur et Ischémie, Université de Caen, Caen;

2. Laboratoire de Physiopathologie Cardiovasculaire, Université Montpellier II, Montpellier; and

3. Equipe Avenir, Institut National de la Santé et de la Recherche Médicale, Université Paris 7, Hôpital Bichat, Service de Néphrologie, Paris, France

Abstract

Calcium-activated nonselective cationic currents have been known for 30 years, but their physiological implications have remained unresolved until the recent cloning of the TRPM4 ion channel. Since then, TRPM4 has been identified as a key modulator of numerous calcium-dependent mechanisms such as the immune response, insulin secretion, cerebral artery constriction, respiratory rhythm, and cardiac conduction.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00004.2010

Reference93 articles.

1. Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells

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5. Voltage-Gated Ion Channels in Human Pancreatic β-Cells: Electrophysiological Characterization and Role in Insulin Secretion

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