The Role of Calmodulin Kinase II in Myocardial Physiology and Disease-Reference-Cited by-同舟云学术

The Role of Calmodulin Kinase II in Myocardial Physiology and Disease

Published:2008-06 Issue:3 Volume:23 Page:151-159
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Couchonnal Luis F.¹,Anderson Mark E.¹²

Affiliation:

1. Departments of Internal Medicine and

2. Molecular Physiology and Biophysics, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine, Iowa City, Iowa,

Abstract

The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates a rich variety of downstream targets in heart. Ca2+homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca2+homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00043.2007

Reference90 articles.

1. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in-Congestive Heart Failure (MERIT-HF)

2. Ca 2+ /Calmodulin–Dependent Protein Kinase Modulates Cardiac Ryanodine Receptor Phosphorylation and Sarcoplasmic Reticulum Ca 2+ Leak in Heart Failure

3. Engineered calmodulins reveal the unexpected eminence of Ca2+ channel inactivation in controlling heart excitation

4. Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes.

5. Anderson ME, Braun AP, Wu Y, Lu T, Wu Y, Schulman H, Sung RJ. KN-93, an inhibitor of multifunctional Ca2+/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart.J Pharmacol Exp Ther287: 996–1006, 1998.

Cited by 114 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. CaMKII protein expression and phosphorylation in human skeletal muscle by immunoblotting: Isoform specificity;Free Radical Biology and Medicine;2024-11

2. CPS1 augments hepatic glucagon response through CaMKII/FOXO1 pathway;Frontiers in Pharmacology;2024-08-13

3. Enhanced Late INa Induces Intracellular Ion Disturbances and Automatic Activity in the Guinea Pig Pulmonary Vein Cardiomyocytes;International Journal of Molecular Sciences;2024-08-09

4. Inflammatory Forms of Cardiomyocyte Cell Death in the Rat Model of Isoprenaline-Induced Takotsubo Syndrome;Biomedicines;2023-07-21

5. Costunolide covalently targets and inhibits CaMKII phosphorylation to reduce ischemia-associated brain damage;Phytomedicine;2023-07