The Athlete's Heart vs. the Failing Heart: Can Signaling Explain the Two Distinct Outcomes?-Reference-Cited by-同舟云学术

The Athlete's Heart vs. the Failing Heart: Can Signaling Explain the Two Distinct Outcomes?

Published:2011-04 Issue:2 Volume:26 Page:97-105
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Weeks Kate L.¹²,McMullen Julie R.¹

Affiliation:

1. Cardiac Hypertrophy Laboratory, Baker IDI Heart and Diabetes Institute, and

2. Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia

Abstract

Cardiac remodeling is typically associated with disease and can lead to heart failure. In contrast, remodeling that occurs in the athlete's heart is considered an adaptive physiological response. This review provides an overview of signaling mechanisms responsible for inducing left ventricular hypertrophy in the athlete's heart and in settings of pathological hypertrophy and heart failure.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00043.2010

Reference110 articles.

1. Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy

2. Metalloproteinases 2 and 9 are increased in plasma of patients with heart failure

3. Release of Preformed Ang II from Myocytes Mediates Angiotensinogen and ET-1 Gene Overexpression In Vivo via AT1 Receptor

4. Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy

5. Ethnic Differences in Left Ventricular Remodeling in Highly-Trained Athletes

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