On, Around, and Through: Neutrophil-Endothelial Interactions in Innate Immunity-Reference-Cited by-同舟云学术

On, Around, and Through: Neutrophil-Endothelial Interactions in Innate Immunity

Published:2011-10 Issue:5 Volume:26 Page:334-347
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Schmidt Eric P.¹,Lee Warren L.²,Zemans Rachel L.¹³,Yamashita Cory⁴,Downey Gregory P.¹²³⁵

Affiliation:

1. Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado;

2. Divisions of Critical Care and Respirology, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada;

3. Departments of Medicine and Pediatrics, Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colorado;

4. Division of Respirology, University of Western Ontario, London, Ontario, Canada; and

5. Integrated Department of Immunology, University of Colorado Denver, Aurora, Colorado

Abstract

This manuscript will review our current understanding of neutrophilic polymorphonuclear leukocyte (neutrophil) interactions with the endothelium during immune and inflammatory responses, focusing on the molecular mechanisms regulating neutrophil adhesion to and migration through the endothelium in response to infection or tissue injury. This is a complex and dynamic area of research and one that has been the topic of several recent comprehensive reviews to which the interested reader is referred ( 64 , 118 , 131 ). By design, this review will begin with a brief review of some basic aspects of neutrophil biology and endothelial adhesion to provide a foundation. The remainder of the review will focus on selected areas of this complex field, specifically the role of the endothelial glycocalyx in regulating neutrophil adhesion and the mechanisms and consequences of migration of neutrophils between (paracellular) and through (transcellular) endothelial cells during egress from the vasculature.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00011.2011

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