Membrane Protein Clusters at Nanoscale Resolution: More Than Pretty Pictures-Reference-Cited by-同舟云学术

Membrane Protein Clusters at Nanoscale Resolution: More Than Pretty Pictures

Published:2010-04 Issue:2 Volume:25 Page:116-124
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Lang Thorsten¹,Rizzoli Silvio O.²

Affiliation:

1. LIMES-Institute, Laboratory of Membrane Biochemistry, University of Bonn, Bonn; and

2. STED-Microscopy of Synaptic Function, European Neuroscience Institute, DFG Center for Molecular Physiology of the Brain, Göttingen, Germany

Abstract

Fluorescence microscopy is powerful for analyzing the composition and dynamics of cellular elements, but studying precise molecule patterns is precluded due to diffraction limited resolution. This barrier has been lifted now through several superresolution microscopy techniques. They revealed that proteins assemble in defined groups (clusters). A new challenge thus appears for the biologist: to find out whether clusters are molecular machines, stabilizers of defined protein conformations, or simply protein reservoirs.

Publisher

American Physiological Society

Subject

Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/physiol.00044.2009

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