Physics and Physiology of Cell Spreading in Two and Three Dimensions-Reference-Cited by-同舟云学术

Physics and Physiology of Cell Spreading in Two and Three Dimensions

Published:2021-11-01 Issue:6 Volume:36 Page:382-391
ISSN:1548-9213
Container-title:Physiology
language:en
Short-container-title:Physiology

Author:

Janmey Paul A.¹^ORCID,Hinz Boris²,McCulloch Christopher A.²

Affiliation:

1. Institute for Medicine and Engineering, Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania

2. Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

Abstract

Cells spread on surfaces and within three-dimensional (3-D) matrixes as they grow, divide, and move. Both chemical and physical signals orchestrate spreading during normal development, wound healing, and pathological states such as fibrosis and tumor growth. Diverse molecular mechanisms drive different forms of cell spreading. This article discusses mechanisms by which cells spread in 2-D and 3-D and illustrates new directions in studies of this aspect of cell function.

Funder

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering

HHS | NIH | National Institute of General Medical Sciences

National Science Foundation

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/physiol.00020.2021

Reference85 articles.

1. Experiment, theory, and the keratocyte: An ode to a simple model for cell motility